Django is a high-level Python Web framework that encourages rapid development and clean, pragmatic design.

Central system and configuration manager: saltstack.org

Machine learning for humans.

A microframework based on Python, Werkzeug, Jinja2 and good intentions.

The source code that powers readthedocs.org

A CMS based on Django. Good first issues are about Python, Django, and also the user interface written in HTML/CSS/JS, some of it with React. There are also UX/design-related open issues.

The Python interface to the Redis key-value store.

Python HTTP Requests for Humans™.

Plone CMS: Open Source Content Management

Simple, Pythonic remote execution and deployment.

Python library implementing the full Github API v3

scikit-learn is a Python module for machine learning built on top of SciPy and distributed under the 3-Clause BSD license.

A library for accessing the Twitter API from Python.

The most popular Django powered CMS.

Static blog generator in Python, using Markdown/reST syntax

Mopidy is a music server which can play music from Spotify and from your local hard drive. It can be controlled using MPD clients, D-Bus clients, and HTTP/WebSocket clients.

Realtime event logging and aggregation platform

err is a plugin based chatbot designed to be easily deployable, extensible and maintainable.

Cheroot is the high-performance, pure-Python HTTP server used by CherryPy.

mrjob lets you write MapReduce jobs in Python 2.5+ and run them on several platforms.